Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?

Nutrients

Anderson P. Jones¹  Meri K. Tulic¹  Kristina Rueter¹ 

[1] School of Paediatrics and Child health, University of Western Australia, Perth, Western Australia 6008, Australia;

关键词: vitamin D;    25(OH)D;    helper T cells;    allergy;    vitamin D receptor;    immune system;   

DOI  :  10.3390/nu4010013

来源: mdpi

【 摘 要 】

A role for vitamin D in the regulation of immune function was first proposed after the identification of Vitamin D Receptors in lymphocytes. It has since been recognized that the active form of vitamin D, 1α,25(OH)2D3, has direct affects on naïve and activated helper T cells, regulatory T cells, activated B cells and dendritic cells. There is a growing body of literature linking vitamin D (serum 25(OH)D, oral intake and surrogate indicators such as latitude) to various immune-related conditions, including allergy, although the nature of this relationship is still unclear. This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.