International Journal of Molecular Sciences | |
Molecular Cloning and Functional Characterization of Tibetan Porcine STING | |
Zhiqing Huang1  Xiaoling Chen1  Keying Zhang1  Bing Yu1  Xiangbing Mao1  Ye Zhao1  | |
[1] Key Laboratory for Animal Disease-Resistance Nutrition of Sichuan Province, Institute of Animal Nutrition, Sichuan Agricultural University, Yaan, Sichuan 625014, China; | |
关键词: cloning; innate immunity; IPEC-J2 cells; Tibetan porcine STING; type I interferon; | |
DOI : 10.3390/ijms13010506 | |
来源: mdpi | |
【 摘 要 】
Tibetan pig is well known for its strong disease resistance. However, little is known about the molecular basis of its strong resistance to disease. Stimulator of interferon (IFN) genes (STING), also known as MPYS/MITA/ERIS/TMEM173, is an adaptor that functions downstream of RIG-I and MAVS and upstream of TBK1 and plays a critical role in type I IFN induction. Here we report the first cloning and characterization of STING gene from Tibetan pig. The entire open reading frame (ORF) of the Tibetan porcine
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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RO202003190046479ZK.pdf | 175KB | download |