Antioxidant Effect of Stryphnodendron rotundifolium Martius Extracts from Cariri-Ceará State (Brazil): Potential Involvement in Its Therapeutic Use

Molecules

José Galberto Martins da Costa¹  Gerlânia de Oliveira Leite¹  Albys Ferrer Dubois¹  Rodrigo Lopes Seeger¹  Aline Augusti Boligon¹  Margareth Linde Athayde¹  Adriana Rolim Campos¹ 

[1] ¹Department of Biological Chemistry, Laboratory of Natural Products, Program of Post-Graduation in Molecular Bioprospection, Regional University of Cariri, Street Cel. Antônio Luiz 1161, Pimenta, 63105-000 Crato-CE, Brazil

关键词: Stryphnodendron rotundifolium;    antioxidant effects;    oxidative stress;    phenolic compounds;    HPLC/DAD;   

DOI  :  10.3390/molecules17010934

来源: mdpi

【 摘 要 】

Stryphnodendron rotundifolium is a phytotherapic used in the northeast of Brazil for the treatment of inflammatory processes which normally are associated with oxidative stress. Consequently, we have tested the antioxidant properties of hydroalcoholic (HAB) and aqueous extracts (AB) from the bark and aqueous extract (AL) from the leaves of Stryphnodendron rotundifolium to determine a possible association between antioxidant activity and the popular use of this plant. Free radical scavenger properties were assessed by the quenching of 1′,1′-diphenil-2-picrylhydrazyl (DPPH) and the calculated IC₅₀ were: HAB = 5.4 ± 0.7, AB = 12.0 ± 2.6, and AL = 46.3 ± 12.3 µg/mL. Total phenolic contents were: HAB = 102.7 ± 2.8, AB = 114.4 ± 14.6, and AL = 93.8 ± 9.1 µg/mg plant). HPLC/DAD analyses indicated that gallic acid, catechin, rutin and caffeic acid were the major components of the crude extracts of S. rotundifolium. Plant extracts inhibited Fe(II)-induced lipid peroxidation in brain homogenates. Iron chelation was also investigated and only HBA exhibited a weak activity. Taken together, the results suggest that S. rotundifolium could be considered an effective agent in the prevention of diseases associated with oxidative stress.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.