Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones

Molecules

Jian-Quan Weng¹  Xing-Hai Liu¹  Hua Huang¹  Cheng-Xia Tan¹ 

[1] ¹College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China ²Department of Bioassay, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023, China

关键词: 3-[(5-aryl-1;    3;    4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones;    synthesis;    crystal structure;    antifungal activity;   

DOI  :  10.3390/molecules17010989

来源: mdpi

【 摘 要 】

A series of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methy])benzo[d]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl₃ under reflux conditions. The structures of the title compounds were confirmed by ¹H-NMR, ¹³C-NMR, IR, MS and elemental analysis. Furthermore, the structure of compound 4i was determined by single-crystal X-ray diffraction. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.