Emerging Viruses in the Felidae: Shifting Paradigms

Viruses

Stephen J. O𠆛rien¹  Jennifer L. Troyer⁴  Meredith A. Brown²  Warren E. Johnson¹  Agostinho Antunes³  Melody E. Roelke⁴ 

[1] Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Frederick, MD 21702, USA;Banfield Pet Hospital, 800 NE Tillamook Street, Portland, OR 97213, USA;CIMAR, University of Porto, Rua dos Bragas, 177, Porto 4050-123, Portugal;SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702, USA;

关键词: FIV;    FCoV;    FeLV;    Felidae;   

DOI  :  10.3390/v4020236

来源: mdpi

【 摘 要 】

The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.