Synthesis and Biological Evaluation of a New Polymeric Conjugate and Nanocarrier with Osteotropic Properties

Journal of Functional Biomaterials

Rosario Pignatello¹  Maria Grazia Sarpietro² 

[1] Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, viale A. Doria 6, Catania I-95125, Italy;

关键词: PLGA;    alendronate;    bone-seeking polymer;    nanoparticles;    biocompatibility;    hemocompatibility;    doxorubicin;    osteolytic tumors;    bone metastasis;   

DOI  :  10.3390/jfb3010079

来源: mdpi

【 摘 要 】

Bone-seeking (osteotropic) drug delivery systems (ODDS) represent an interesting solution for targeting different types of drugs to the bones. In particular, anticancer and antibacterial agents could take advantage of such therapeutic strategy. We have recently developed an innovative approach to this aim: a new osteotropic biomaterial was prepared, based on the conjugation of a poly(lactide-co-glycolide) (PLGA) with the bisphosphonate drug alendronate (PLGA-ALE); its hemo- and cytocompatibility were verified. Starting with this copolymer, an osteotropic nanoparticle system (NP) was produced for the targeted delivery of antineoplastic drugs to osteolytic bone metastases; in particular, doxorubicin was tested as a model drug. The in vitro and in vivo results of the new ODDS are validated in this article. All the experimental data confirmed that the drug retained its activity after loading in the PLGA-ALE NP; they can be thus considered a new promising strategy for active targeting of drugs to bone tissues in different pathological situations.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.