International Journal of Molecular Sciences | |
The Effect of Secretory Factors of Adipose-Derived Stem Cells on Human Keratinocytes | |
Kyoung Mi Moon4  Ye-Hyoung Park1  Jae Seol Lee4  Yong-Byung Chae2  Moon-Moo Kim2  Dong-Soo Kim1  Byung-Woo Kim3  Soo-Wan Nam4  | |
[1] Prostemics Research Institute, Seoul 135-816, Korea; E-Mails:;Department of Chemistry, Dong-Eui University, Busan 614-714, Korea; E-Mails:;Blue-Bio Regional Innovation Center, Dong-Eui University, Busan 614-714, Korea; E-Mail:;Department of Biomaterial Control, Dong-Eui University, Busan 614-714, Korea; E-Mails: | |
关键词: ADSC-CM; AAPE; stress fiber formation; RhoA-ROCK signaling; regeneration; proliferation; migration; | |
DOI : 10.3390/ijms13011239 | |
来源: mdpi | |
【 摘 要 】
The beneficial effects of adipose-derived stem cell conditioned medium (ADSC-CM) on skin regeneration have been reported. Although the mechanism of how ADSC-CM promotes skin regeneration is unclear, ADSC-CM contained various growth factors and it is an excellent raw material for skin treatment. ADSC-CM produced in a hypoxia condition of ADSC—in other words, Advanced Adipose-Derived Stem cell Protein Extract (AAPE)—has great merits for skin regeneration. In this study, human primary keratinocytes (HKs), which play fundamental roles in skin tissue, was used to examine how AAPE affects HK. HK proliferation was significantly higher in the experimental group (1.22 μg/mL) than in the control group. DNA gene chip demonstrated that AAPE in keratinocytes (
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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RO202003190046093ZK.pdf | 506KB | download |