Applications of Aptasensors in Clinical Diagnostics

Sensors

Ping Hong¹  Wenli Li¹ 

[1] National Center for Clinical Laboratories, Beijing Hospital, Beijing 100730, China; E-Mails:

关键词: biosensor;    aptamer;    aptasensors;    clinical diagnostics;   

DOI  :  10.3390/s120201181

来源: mdpi

【 摘 要 】

Aptamers are artificial oligonucleotides (DNA or RNA) selected in vitro that bind a broad range of targets with high affinity and specificity; a sensitive yet simple method to utilize aptamers as recognition elements for the development of biosensors (aptasensors) is to transduce the signal electrochemically. So far, aptasensors have been applied to clinical diagnostics and several technologies are in development. Aptasensors will extend the limits of current clinical diagnostics. Although the potential diagnostic applications are unlimited, the most current applications are foreseen in the areas of biomarker detection, cancer clinical testing, detection of infectious microorganisms and viruses. This review attempts to list examples of the research progresses of aptamers in biosensor platforms that have been published in recent years; in particular, we display cases of aptasensors that are already incorporated in clinical diagnostics or have potential applications in clinical diagnostics.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland