The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?

Toxins

关键词: Shiga toxins;    ricin;    ribosome-inactivating proteins;    polymorphonuclear leukocytes;    hemolytic uremic syndrome;   

DOI  :  10.3390/toxins4030157

来源: mdpi

【 摘 要 】

Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that recognizes molecular patterns common to foreign molecules through specific receptors expressed on the surface of the main actors of innate immunity, namely monocytes and neutrophils. The interactions between these toxins and neutrophils have been widely described and have stimulated intense debate. This paper is aimed at reviewing the topic, focusing particularly on implications for the pathogenesis and diagnosis of hemolytic uremic syndrome.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.