Bioactive Phenolic Amides from Celtis africana

Molecules

Areej Mohammad Al-Taweel¹  Shagufta Perveen¹  Azza Muhammed El-Shafae¹  Ghada Ahmed Fawzy¹  Abdul Malik¹  Nighat Afza¹  Lubna Iqbal¹ 

[1] ¹Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia

关键词: Celtis africana;    antioxidant;    anti-inflammatory;    acetylcholinestrease enzyme inhibition;   

DOI  :  10.3390/molecules17032675

来源: mdpi

【 摘 要 】

Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 1–3 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.