Nutrients | |
Immunological Function of Sphingosine 1-Phosphate in the Intestine | |
Jun Kunisawa1  | |
[1] Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan | |
关键词: intestinal immunity; lipid; IgA antibody; intraepithelial T lymphocytes; food allergy; | |
DOI : 10.3390/nu4030154 | |
来源: mdpi | |
【 摘 要 】
It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190045696ZK.pdf | 1296KB | download |