Immunological Function of Sphingosine 1-Phosphate in the Intestine

Nutrients

Jun Kunisawa¹ 

[1] Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

关键词: intestinal immunity;    lipid;    IgA antibody;    intraepithelial T lymphocytes;    food allergy;   

DOI  :  10.3390/nu4030154

来源: mdpi

【 摘 要 】

It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.