The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis

International Journal of Molecular Sciences

Jing Wang¹  Hong Lu¹  Yingzhi Xu¹  Xiaofeng Hu¹  Wei Chen² 

[1] Department of Ophthalmology, Chaoyang Hospital, Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China; E-Mails:;Department of Ophthalmology, Haidian Maternal and Child Health Hospital, Tongji Medical University, Beijing 100080, China; E-Mail:

关键词: Toll-like receptor 4;    Cytokine;    cytometric bead array technology;    aqueous humor;    Anterior Uveitis;   

DOI  :  10.3390/ijms13022110

来源: mdpi

【 摘 要 】

In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.