Allylic Alkylations Catalyzed By Palladium-Bis(oxazoline) Complexes Derived From Heteroarylidene Malonate Derivatives

Molecules

Lei Liu¹  Hongli Ma¹ 

[1] Department of Applied Chemistry, China Agricultural University, Beijing 100193, China

关键词: bis(oxazoline);    asymmetric catalysis;    allylic alkylation;   

DOI  :  10.3390/molecules17021992

来源: mdpi

【 摘 要 】

A series of simple heteroarylidene malonate-type bis(oxazoline) ligands 4 and 5 were applied to the Palladium-catalyzed allylic alkylation reaction, and the ligand 4a bearing a phenyl group afforded excellent enantioselectivity (up to 96% ee) for the allylic alkylation product. Other substrates were also examined, giving the allylic alkylated products in high yield but with poor ee values.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.