A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment Sample

Marine Drugs

Yan Li¹  Dezan Ye²  Zongze Shao²  Chengbin Cui¹ 

[1] Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China;Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen 361005, China;

关键词: Penicillium sp.;    deep sea sediment;    sterol;    spiroditerpenoids;    cytotoxicity;   

DOI  :  10.3390/md10020497

来源: mdpi

【 摘 要 】

A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I–K (2–4), and the known breviones (5–8), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 1–4 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.