Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata

Molecules

Chia-Chun Yu¹  Ching-Ruey Hsieh¹  George Hsiao¹  Pi-Yu Chen¹  Meng-Lun Chang¹  Hwa-Wen Yin¹  Tzong-Huei Lee¹ 

[1] ¹Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan

关键词: Euphorbia formosana;    abietane diterpene;    MMP-2;    -9;    HT-1080;   

DOI  :  10.3390/molecules17022082

来源: mdpi

【 摘 要 】

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.