Biomarker Gene Signature Discovery Integrating Network Knowledge

Biology

Yupeng Cun¹ 

[1] Bonn-Aachen International Center for IT (B-IT), Dahlmannstr. 2, 53113 Bonn, Germany;

关键词: biomarker;    gene selection;    protein-protein interactions network;    personalized medicine;   

DOI  :  10.3390/biology1010005

来源: mdpi

【 摘 要 】

Discovery of prognostic and diagnostic biomarker gene signatures for diseases, such as cancer, is seen as a major step towards a better personalized medicine. During the last decade various methods, mainly coming from the machine learning or statistical domain, have been proposed for that purpose. However, one important obstacle for making gene signatures a standard tool in clinical diagnosis is the typical low reproducibility of these signatures combined with the difficulty to achieve a clear biological interpretation. For that purpose in the last years there has been a growing interest in approaches that try to integrate information from molecular interaction networks. Here we review the current state of research in this field by giving an overview about so-far proposed approaches.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.