International Journal of Molecular Sciences | |
A Combined DNA-Affinic Molecule and N-Mustard Alkylating Agent Has an Anti-Cancer Effect and Induces Autophagy in Oral Cancer Cells | |
Wen-Liang Lo5  Pen-Yuan Chu4  Tsung-Heng Lee2  Tsann-Long Su1  Yueh Chien3  Yi-Wei Chen3  Pin-I Huang3  Ling-Ming Tseng3  Pang-Hsien Tu1  Shou-Yen Kao5  | |
[1] Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan; E-Mails:;Department of Dentistry, Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei 11217 Taiwan; E-Mail:;Institute of Clinical Medicine, National Yang-Ming University, Taipei 11217 Taiwan; E-Mails:;Laryngology and Head and Neck Surgery, Department of Otolaryngology, Taipei Veterans General Hospital, Taipei 11217 Taiwan; E-Mail:;Division of Oral and Maxillofacial Surgery, Department of Stomatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan; E-Mail: | |
关键词: BO-1051; AVO; autophagy; cell cycle; checkpoint kinases; | |
DOI : 10.3390/ijms13033277 | |
来源: mdpi | |
【 摘 要 】
Although surgery or the combination of chemotherapy and radiation are reported to improve the quality of life and reduce symptoms in patients with oral cancer, the prognosis of oral cancer remains generally poor. DNA alkylating agents, such as N-mustard, play an important role in cancer drug development. BO-1051 is a new 9-anilinoacridine N-mustard-derivative anti-cancer drug that can effectively target a variety of cancer cell lines and inhibit tumorigenesis
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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