Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases

Molecules

Guo-Ying Zuo¹  Xin-Juan Zhang¹  Cui-Xian Yang¹  Jun Han¹  Gen-Chun Wang¹ 

[1] ¹Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China

关键词: Chinese medicinal plants;    traditional Chinese medicine (TCM);    methicillin-resistant Staphylococcus aureus (MRSA);    inhibition zone diameters (IZD);    minimal bactericidal concentrations (MIC);   

DOI  :  10.3390/molecules17032955

来源: mdpi

【 摘 要 】

The in vitro antimicrobial activities of 30 Chinese medicinal plants were evaluated with reference to the treatment record of infectious diseases in the Traditional Chinese Medicine (TCM) literature. The plant materials were extracted with 80% ethanol and the extracts were primarily screened against conventional clinical pathogens like Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans by the agar diffusion method. Their inhibition zone diameters (IZDs, mm, 50 mg/mL) ranged from 2,048 by the standard broth microdilution method. The seven extracts from M. yunnanensis, S. sinensis, G. morella, E. daneillii, M. squamulata, S. arborescens and B. hancei were determined as the most active extracts, with MICs of 8–64 μg/mL. The results were in good agreement with their traditional applications in skin and other infections.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.