Synthesis of Amino Core Compounds of Galactosyl Phytosyl Ceramide Analogs for Developing iNKT-Cell Inducers

Molecules

Yin-Cheng Huang¹  Li-Wu Chiang¹  Kai-Shiang Chang¹  Wen-Chin Su¹  Yi-Hsian Lin¹  Kee-Ching Jeng¹  Kun-I Lin¹  Kuo-Yen Liao¹  Ho-Lein Huang¹ 

[1] ¹Department of Neurosurgery, Chang Gung Memorial Hospital and Department of Medicine, Chang Gung University, Taoyuan 33305, Taiwan

关键词: phytosphingosine;    library;    cancer;    immune;    glycosylation;   

DOI  :  10.3390/molecules17033058

来源: mdpi

【 摘 要 】

1-Aminophytosphingosine and 6-aminogalactosyl phytosphingosine were prepared in 61% and 40% yield libraries with 44 carboxylic acids showed that a 4-butylbenzoic acid-derived product exe, respectively. Glycosylation using benzoyl-protected lipid resulted in better a-selectivity for ceramide analogs, but the yield was less than that obtained with benzyl moieties. Screening the amide rted less cytotoxicity. These analogs were purified for validation of immunological potencies and the a-GalCer analog but not the sphingosine analog stimulated human iNKT cell population.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.