Anti-acetylcholinesterase and Antioxidant Activity of Essential Oils from Hedychium gardnerianum Sheppard ex Ker-Gawl

Molecules

Miguel Arruda¹  Hugo Viana¹  Nuno Rainha¹  Nuno R. Neng¹  José Silvino Rosa¹  José M. F. Nogueira¹ 

[1] ¹Department of Technological Sciences and Development (DCTD), University of Azores, Rua Mãe de Deust, 9501-801 Ponta Delgada, Portugal

关键词: Hedychium gardnerianum;    essential oils;    anti-acetylcholinesterasic activity;    antioxidant activity;    Alzheimer’s disease;   

DOI  :  10.3390/molecules17033082

来源: mdpi

【 摘 要 】

Acetylcholinesterase inhibition, antioxidant and cytotoxic activities of Hedychium gardnerianum leaf essential oils from S. Miguel Island were determined. All the oils inhibited acetylcholinesterase, with IC₅₀ values of approximately 1 mg/mL, showing no statistical differences between collection sites. Three oils presented mixed inhibition, whilst one was almost truly competitive. This activity can be attributed to the presence of sesquiterpenes, which constituted more than 60% of the composition of the oils. Regarding the antioxidant activity as measured by the DPPH method, all the oils presented activities similar to reference compounds, although with statistical differences between collection sites. Cytotoxicity measured using Artemia salina classified these oils as moderately toxic, with LC₅₀ values ranging from 300 to 500 µg/mL. These results indicate a possible application of these oils in aromatherapy as coadjuvants in the treatment of cognitive diseases such as Alzheimer, since they may contribute to increase acetylcholine in cholinergic neurons and simultaneously fight deleterious oxidations responsible by neurological degeneration.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.