Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3

Molecules

Han Wang¹  Kun Wen²  Le Wang²  Ye Xiang²  Xiaocheng Xu²  Yongjia Shen¹ 

[1]School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China

[2]College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China

关键词: solvent-free;    chlorination;    phosphorous oxychloride (POCl₃);   

DOI  :  10.3390/molecules17044533

来源: mdpi

【 摘 要 】

Chlorination with equimolar POCl₃ can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.