Sensors | |
A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication | |
Min Guo1  Sonja Gamby1  Shizuka Nakayama1  Jacqueline Smith1  | |
[1] Department of Chemistry and Biochemistry, University of Maryland, Building 091, College Park, MD 20742, USA; | |
关键词:
AI-2;
DPD analog;
quorum sensing inhibitor;
ester pro-drug;
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DOI : 10.3390/s120303762 | |
来源: mdpi | |
【 摘 要 】
The universal quorum sensing autoinducer, AI-2, is utilized by several bacteria. Analogs of AI-2 have the potential to modulate bacterial behavior. Selectively quenching the communication of a few bacteria, in the presence of several others in an ecosystem, using analogs of AI-2 is non-trivial due to the ubiquity of AI-2 processing receptors in many bacteria that co-exist. Herein, we demonstrate that when an AI-2 analog, isobutyl DPD (which has been previously shown to be a quorum sensing, QS, quencher in both
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190045220ZK.pdf | 664KB | download |