Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents

International Journal of Molecular Sciences

Vanessa dos Santos Temponi²  Jucélia Barbosa da Silva²  Maria Silvana Alves¹  Antônia Ribeiro³  José de Jesus Ribeiro Gomes de Pinho¹  Célia Hitomi Yamamoto¹  Miriam Aparecida Oliveira Pinto¹  Glauciemar Del-Vechio-Vieira¹ 

[1] Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil; E-Mails:;Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil; E-Mails:;Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora 36036-330, Brazil; E-Mail:

关键词: Vernonia polyanthes;    antinociceptive effect;    anti-inflammatory effect;   

DOI  :  10.3390/ijms13033887

来源: mdpi

【 摘 要 】

The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.