International Journal of Molecular Sciences | |
Dihydrolipoic Acid Induces Cytotoxicity in Mouse Blastocysts through Apoptosis Processes | |
Wei-Li Houng1  Cheng-An J. Lin3  Ji-Lin Shen2  Hung-I Yeh4  Hsueh-Hsiao Wang4  Walter H. Chang3  | |
[1] Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li 32023, Taiwan; E-Mail:;Department of Physics, Chung Yuan Christian University, Chung Li 32023, Taiwan; E-Mail:;Department of Biomedical Engineering and Center for Nano Bioengineering, Chung Yuan Christian University, Chung-Li 32023, Taiwan; E-Mail:;Departments of Internal Medicine and Medical Research, Mackay Memorial Hospital, Mackay Medical College, New Taipei City 252, Taiwan; E-Mails: | |
关键词: dihydrolipoic acid; blastocyst; apoptosis; embryonic development; | |
DOI : 10.3390/ijms13033988 | |
来源: mdpi | |
【 摘 要 】
α-Lipoic acid (LA) is a thiol with antioxidant properties that protects against oxidative stress-induced apoptosis. LA is absorbed from the diet, taken up by cells and tissues, and subsequently reduced to dihydrolipoic acid (DHLA). In view of the recent application of DHLA as a hydrophilic nanomaterial preparation, determination of its biosafety profile is essential. In the current study, we examined the cytotoxic effects of DHLA on mouse embryos at the blastocyst stage, subsequent embryonic attachment and outgrowth
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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RO202003190045180ZK.pdf | 374KB | download |