Endogenous Bioactive Peptides as Potential Biomarkers for Atherosclerotic Coronary Heart Disease

Sensors

Takuya Watanabe¹  Kengo Sato¹  Fumiko Itoh¹  Kohei Wakabayashi³  Masayoshi Shichiri² 

[1] Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-City, Tokyo 192-0392, Japan; E-Mails:;Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; E-Mail:;Division of Cardiology, Showa University Fujigaoka Hospital, Yokohama, Kanagawa 227-8501, Japan; E-Mail:

关键词: acyl-coenzyme A: cholesterol acyltransferase-1;    adiponectin;    atherosclerosis;    biomarker;    coronary artery disease;    glucagon-like peptide-1;    heregulin-β₁;    macrophage;    salusin-α;   

DOI  :  10.3390/s120404974

来源: mdpi

【 摘 要 】

Cardiovascular disease is the leading cause of death worldwide, with high medical costs and rates of disability. It is therefore important to evaluate the use of cardiovascular biomarkers in the early diagnosis of coronary artery disease (CAD). We have screened a variety of recently identified bioactive peptides candidates in anticipation that they would allow detection of atherosclerotic CAD. Especially, we have focused on novel anti-atherogenic peptides as indicators and negative risk factors for CAD. In vitro, in vivo and clinical studies indicated that human adiponectin, heregulin-β₁, glucagon-like peptide-1 (GLP-1), and salusin-α, peptides of 244, 71, 30, and 28 amino acids, respectively, attenuate the development and progression of atherosclerotic lesions by suppressing macrophage foam cell formation via down-regulation of acyl-coenzyme A: cholesterol acyltransferase-1. Circulating levels of these peptides in the blood are significantly decreased in patients with CAD compared to patients without CAD. Receiver operating characteristic analyses showed that salusin-α is a more useful biomarker, with better sensitivity and specificity, compared with the others for detecting CAD. Therefore, salusin-α, heregulin-β₁, adiponectin, and/or GLP-1, alone or in various combinations, may be useful as biomarkers for atherosclerotic CAD.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland