HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification

Sensors

Adam J. Kimple¹  Alexandra D. Torres²  Robert Z. Yang² 

[1] School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; E-Mail:;Department of Human Oncology, University of Wisconsin, Madison, WI 53706, USA; E-Mails:

关键词: human papillomavirus;    head and neck cancer;    in situ hybridization;    next generation sequencing;    biomarkers;   

DOI  :  10.3390/s120405159

来源: mdpi

【 摘 要 】

Over the last 10 years, it has become clear that patients with head and neck cancer can be stratified into two distinct subgroups on the basis of the etiology of their disease. Patients with human papillomavirus-related cancers have significantly better survival rates and may necessitate different therapeutic approaches than those with tobacco and/or alcohol related cancers. This review discusses the various biomarkers currently in use for identification of patients with HPV-positive cancers with a focus on the advantages and limitations of molecular and nano-scale markers.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.