Genes | |
Case Study of Sequence Capture Enrichment Technology: Identification of Variation Underpinning Developmental Syndromes in an Amniote Model | |
Elizabeth A. Robb1  | |
[1] Department of Animal Science, University of California, Davis, CA 95616, USA; E-Mail | |
关键词: capture array; next generation sequencing; bioinformatics; chicken; mutation; SNP; variant; indel; congenic; | |
DOI : 10.3390/genes3020233 | |
来源: mdpi | |
【 摘 要 】
Chicken developmental mutants are valuable for discovering sequences and pathways controlling amniote development. Herein we applied the advanced technologies of targeted sequence genomic capture enrichment and next-generation sequencing to discover the causative element for three inherited mutations affecting craniofacial, limb and/or organ development. Since the mutations (
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190044931ZK.pdf | 399KB | download |