Fucanomics and Galactanomics: Marine Distribution, Medicinal Impact, Conceptions, and Challenges

Marine Drugs

关键词: fucanome;    fucanomics;    galactanome;    galactanomics;    glycome;    glycomics;    sulfated fucan;    sulfated galactan;   

DOI  :  10.3390/md10040793

来源: mdpi

【 摘 要 】

Glycomics turned out to be a very extensive project where its subdivision is consequently emerging. This is seen by the growing number of terminologies used to define subprojects concerning particular classes of bioactive carbohydrates. Sulfated fucans (SFs) and sulfated galactans (SGs) are relatively new classes of sulfated polysaccharides (SPs) that occur mostly in marine organisms, and exhibit a broad range of medicinal effects. Their structures are taxonomically dependent, and their therapeutic actions include benefits in inflammation, coagulation, thrombosis, angiogenesis, cancer, oxidation, and infections. Some red algae, marine angiosperm and invertebrates express SPs of unique structures composed of regular repeating oligomeric units of well-defined sulfation patterns. This fine pattern of structural regularity is quite rare among any naturally occurring long SPs, and enables accurate structure-biofunction correlations. Seeing that, fucanomics and galactanomics may comprise distinguished glycomics subprojects. We hereby discuss the relevance that justifies the international recognition of these subprojects in the current glycomics age associated with the beneficial outcomes that these glycans may offer in drug development.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.