Synthesis and Herbicidal Activity Evaluation of Novel β-Carboline Derivatives

Molecules

Qunfang Weng¹  Jingfei Huang¹  Yong Zeng¹  Yueye Deng¹ 

[1] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Guangzhou 510642, China;

关键词: -substituted-1"'>N'-substituted-1;    2;    3;    4-β-tetrahydro-β-carboline-3-carbohydrazide;    β-carboline;    -substituted-β-carboline-3-carbohydrazides"'>N'-substituted-β-carboline-3-carbohydrazides;    1-substituted-β-carboline-3-carbohydrazides;    herbicidal activity;   

DOI  :  10.3390/molecules17043969

来源: mdpi

【 摘 要 】

Based on the original structure of harmine, several novel 1,2,3,4-tetrahydro-β-carboline, β-carboline and 1-substituted-β-carboline derivatives bearing a substituted carbohydrazide group at C-3 were designed and synthesized to investigate the structure-activity relationship of their analogues. All of the compounds were characterized by infrared (IR), proton and carbon nuclear magnetic resonance (¹H-NMR, ¹³C-NMR), and mass spectroscopy (MS). The bioassay tests showed that N'-benzylidene-1-phenyl-β-carboline-3-carbohydrazide (C₂₅H₁₈N₄O, m.w. 390.4) (c2) and N'-(4-trifluoromethyl-benzylidene)-1-phenyl-β-carboline-3-carbohydrazide (C₂₆H₁₇N₄OF₃, m.w. 458) (d2) exhibited good inhibitory activity against dicotyledonous and monocotyledonous weeds, with EC₅₀ values of 4.83 µM and 14.25 µM, respectively.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.