Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

Sensors

Zsolt Gelencsér¹  Kumari Sonal Choudhary²  Bruna Goncalves Coutinho²  Sanjarbek Hudaiberdiev²  Borisz Galbáts¹  Vittorio Venturi² 

[1] Faculty of Information Technology, PázmányPéter Catholic University, Práter u. 50/a, Budapest 1083, Hungary; E-Mails:;International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste 32149, Italy; E-Mails:

关键词: quorum sensing;    N-AHL;    topology;    proteobacteria;    bacteria;   

DOI  :  10.3390/s120505432

来源: mdpi

【 摘 要 】

Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.