Synthesis and Antimicrobial Evaluation of Some Pyrazole Derivatives

Molecules

Essam Mohamed Sharshira¹ 

[1] ¹Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt ²Department of Chemistry, Faculty of Education, Alexandria University, Alexandria 21526, Egypt

关键词: isonicotinic acid hydrazide;    sulphonamide;    pyrazoles;    antimicrobial activities;   

DOI  :  10.3390/molecules17054962

来源: mdpi

【 摘 要 】

Reaction of a series of (E)-3-phenyl-4-(p-substituted phenyl)-3-buten-2-ones with p-sulfamylphenyl hydrazine in glacial acetic acid gave the corresponding hydrazones, subsequent treatment of which with 30% HCl afforded pyrazole-1-sulphonamides. On the other hand, refluxing of chalcones with either thiosemicarbazide or isonicotinic acid hydrazide in ethanol containing a few drops of acetic acid gave pyrazoline-1-thiocarboxamides and isonicotinoyl pyrazolines, respectively. The structures of the synthesized compounds were determined on the basis of their elemental analyses and spectroscopic data. The antimicrobial activity of the newly isolated heterocyclic compounds was evaluated against Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed a moderate degree of potent antimicrobial activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.