Iron Oxide Nanocrystals for Magnetic Hyperthermia Applications

Nanomaterials

Leisha M. Armijo¹  Yekaterina I. Brandt¹  Dimple Mathew¹  Surabhi Yadav¹  Salomon Maestas¹  Antonio C. Rivera¹  Nathaniel C. Cook¹  Nathan J. Withers¹  Gennady A. Smolyakov¹  Natalie Adolphi²  Todd C. Monson³  Dale L. Huber⁵  Hugh D. C. Smyth⁴ 

[1] Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA;Department of Biochemistry and Molecular Biology, Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA;Sandia National Laboratories, Nanomaterials Sciences, P.O. Box 5800, MS 1415, Albuquerque, NM 87185, USA;College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA;Center for Integrated Nanotechnologies, Sandia National Laboratories, 1000 Eubank SE, Albuquerque, NM 87123, USA;

关键词: iron oxide nanocrystals;    hyperthermia;    thermotherapy;    ferrofluid;   

DOI  :  10.3390/nano2020134

来源: mdpi

【 摘 要 】

Magnetic nanocrystals have been investigated extensively in the past several years for several potential applications, such as information technology, MRI contrast agents, and for drug conjugation and delivery. A specific property of interest in biomedicine is magnetic hyperthermia—an increase in temperature resulting from the thermal energy released by magnetic nanocrystals in an external alternating magnetic field. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Polymorphous nanocrystals as well as spherical nanocrystals and nanowires in paramagnetic to ferromagnetic size range exhibited good heating power. A remarkable 30 °C temperature increase was observed in a nanowire sample at 111 kHz and magnetic field of 25 mT (19.6 kA/m), which is very close to the typical values of 100 kHz and 20 mT used in medical treatments.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.