Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

Molecules

Wen-Yan Li¹  Xu-Qiong Xiong¹  Dong-Mei Zhao¹  Yu-Fang Shi¹  Zhi-Heng Yang¹  Chao Yu¹  Pei-Wei Fan¹  Mao-Sheng Cheng¹ 

[1] ¹Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China ²Central Research Institute, Shanghai Pharmaceuticals Holding Co., Ltd., Shanghai 201203, China

关键词: CETP inhibitors;    CETP;    quinoline-3-carboxamide derivatives;    synthesis;    high density lipoprotein cholesterol;   

DOI  :  10.3390/molecules17055497

来源: mdpi

【 摘 要 】

A series of novel quinoline-3-carboxamide derivatives 10–17 and 23–27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.