Sol-Gel-Derived Hydroxyapatite-Carbon Nanotube/Titania Coatings on Titanium Substrates

International Journal of Molecular Sciences

Xiaoli Ji²  Weiwei Lou²  Qi Wang¹  Jianfeng Ma²  Haihong Xu²  Qing Bai²  Chuantong Liu² 

[1] State Key Laboratory of Oral Diseases, West China Stomatology Hospital, Sichuan University, Chengdu 610041, China; E-Mail:;Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical College, Wenzhou 325027, China; E-Mails:

关键词: hydroxyapatite;    carbon nanotubes;    titania;    anodization;    sol-gel process;   

DOI  :  10.3390/ijms13045242

来源: mdpi

【 摘 要 】

In this paper, hydroxyapatite-carbon nanotube/titania (HA-CNT/TiO₂) double layer coatings were successfully developed on titanium (Ti) substrates intended for biomedical applications. A TiO₂ coating was firstly developed by anodization to improve bonding between HA and Ti, and then the layer of HA and CNTs was coated on the surface by the sol-gel process to improve the biocompatibility and mechanical properties of Ti. The surfaces of double layer coatings were uniform and crack-free with a thickness of about 7 μm. The bonding strength of the HA-CNT/TiO₂ coating was higher than that of the pure HA and HA-CNT coatings. Additionally, in vitro cell experiments showed that CNTs promoted the adhesion of preosteoblasts on the HA-CNT/TiO₂ double layer coatings. These unique surfaces combined with the osteoconductive properties of HA exhibited the excellent mechanical properties of CNTs. Therefore, the developed HA-CNT/TiO₂ coatings on Ti substrates might be a promising material for bone replacement.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.