Influence of Mycotoxins and a Mycotoxin Adsorbing Agent on the Oral Bioavailability of Commonly Used Antibiotics in Pigs

Toxins

Joline Goossens⁵  Virginie Vandenbroucke⁵  Frank Pasmans²  Siegrid De Baere⁵  Mathias Devreese⁵  Ann Osselaere⁵  Elin Verbrugghe²  Freddy Haesebrouck²  Sarah De Saeger³  Mia Eeckhout⁴  Kris Audenaert¹  Geert Haesaert¹  Patrick De Backer⁵ 

[1] Department of Plant Production, Faculty of Applied Bioscience Engineering, University College Ghent, Valentin Vaerwyckweg 1, 9000 Gent, Belgium;Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium;Department of Food Science and Technology, Faculty of Applied Bioscience Engineering, University College Ghent, Valentin Vaerwyckweg 1, 9000 Gent, Belgium;Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;

关键词: mycotoxins;    mycotoxin binder;    antibiotics;    pigs;    interaction;    safety testing;   

DOI  :  10.3390/toxins4040281

来源: mdpi

【 摘 要 】

It is recognized that mycotoxins can cause a variety of adverse health effects in animals, including altered gastrointestinal barrier function. It is the aim of the present study to determine whether mycotoxin-contaminated diets can alter the oral bioavailability of the antibiotics doxycycline and paromomycin in pigs, and whether a mycotoxin adsorbing agent included into diets interacts with those antibiotics. Experiments were conducted with pigs utilizing diets that contained blank feed, mycotoxin-contaminated feed (T-2 toxin or deoxynivalenol), mycotoxin-contaminated feed supplemented with a glucomannan mycotoxin binder, or blank feed supplemented with mycotoxin binder. Diets with T-2 toxin and binder or deoxynivalenol and binder induced increased plasma concentrations of doxycycline administered as single bolus in pigs compared to diets containing blank feed. These results suggest that complex interactions may occur between mycotoxins, mycotoxin binders, and antibiotics which could alter antibiotic bioavailability. This could have consequences for animal toxicity, withdrawal time for oral antibiotics, or public health.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.