Cancers | |
T-Cell Mediated Immune Responses Induced in |
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Oliver Abschuetz4  Wolfram Osen3  Kathrin Frank4  Masashi Kato2  Dirk Schadendorf1  | |
[1] Department of Dermatology, University Hospital Essen, Essen 45122, Germany;Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Aichi 487-8501, Japan;Division of Translational Immunology, German Cancer Center, Heidelberg 69120, Germany;Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim , Heidelberg 69120, Germany | |
关键词: melanoma; transgenic mouse model; T cells; immunization; cytokines; melanoma associated antigens; | |
DOI : 10.3390/cancers4020490 | |
来源: mdpi | |
【 摘 要 】
Poor response of human malignant melanoma to currently available treatments requires a development of innovative therapeutic strategies. Their evaluation should be based on animal models that resemble human melanoma with respect to genetics, histopathology and clinical features. Here we used a transgenic mouse model of spontaneous skin melanoma, in which the
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190044378ZK.pdf | 1411KB | download |