In Vitro Antioxidant and Anti-Proliferation Activities of Polysaccharides from Various Extracts of Different Mushrooms

International Journal of Molecular Sciences

Xiaoyu Li²  Zhenyu Wang²  Lu Wang²  Elfalleh Walid¹ 

[1] Institut des Régions Arides de Médenine, Laboratoire d’Aridoculture et Cultures Oasiennes, Médenine 4119, Tunisia; E-Mail:;Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, China; E-Mails:

关键词: mushrooms;    polysaccharides;    antioxidant;    anti-proliferation;   

DOI  :  10.3390/ijms13055801

来源: mdpi

【 摘 要 】

Polysaccharides were extracted from eight kinds of Chinese mushrooms using three solvents and were evaluated for their total carbohydrate, polyphenolic and protein contents, and antioxidant and anti-proliferation activities. The results suggested that all the polysaccharides had significant antioxidant capacities (EC₅₀ ranged from 1.70 ± 0.42 to 65.98 ± 1.74 μM TE/g crude polysaccharide inhibition of ABTS⁺, EC₅₀ ranged from 5.06 ± 0.12 to 127.38 ± 1.58 mg VCE/g CP scavenging of OH· and EC₅₀ ranged from 0.70 ± 0.04 to 33.54 ± 0.49 mg VCE/g CP inhibition of lipid peroxidation) (TE: trolox equivalent; VCE: VC equivalent; CP: crude polysaccharide). The acid extracts of Russula vinosa Lindblad had the highest ABTS⁺ scavenging activity. Aqueous extracts of Dictyophora indusiata and Hohenbuehelia serotina possessed, respectively, the highest OH· scavenging capacity and ability to inhibit lipid peroxidation. Mushroom extracts also inhibited proliferation of HeLa and HepG2 cells in a dose-dependent manner. These results indicate that the mushroom polysaccharides might be potential antioxidant resources.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.