Biological Properties of Acidic Cosmetic Water from Seawater

International Journal of Molecular Sciences

Wei-Ting Liao⁴  Tsi-Shu Huang⁵  Chien-Chih Chiu⁴  Jian-Liang Pan⁷  Shih-Shin Liang⁴  Bing-Hung Chen⁴  Shi-Hui Chen⁶  Po-Len Liu²  Hui-Chun Wang³  Zhi-Hong Wen¹  Hui-Min Wang⁸ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70, Lien-Hai Rd, Kaohsiung 804, Taiwan; E-Mail:;Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 807, Taiwan; E-Mail:;Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-Mail:;Department of Biotechnology, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 807, Taiwan; E-Mails:;Section of Microbiology, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 807, Taiwan; E-Mail:;Department of Research and Development, Taiyen Biotech Co., Ltd., 15, Gong-Huan Road, Annan District, Tainan 709, Taiwan; E-Mail:;Department of Chemical and Biochemical Engineering, Kao Yuan University, Kaohsiung 821, Taiwan; E-Mail:;Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 807, Taiwan

关键词: acidic cosmetic water (ACW);    antioxidant activity;    anti-microorganism;    anti-inflammation;    allergy-free;    skin-whitening;    anti-melanoma;   

DOI  :  10.3390/ijms13055952

来源: mdpi

【 摘 要 】

This current work was to investigate the biological effects of acidic cosmetic water (ACW) on various biological assays. ACW was isolated from seawater and demonstrated several bio-functions at various concentration ranges. ACW showed a satisfactory effect against Staphylococcus aureus, which reduced 90% of bacterial growth after a 5-second exposure. We used cultured human peripheral blood mononuclear cells (PBMCs) to test the properties of ACW in inflammatory cytokine release, and it did not induce inflammatory cytokine release from un-stimulated, normal PBMCs. However, ACW was able to inhibit bacterial lipopolysaccharide (LPS)-induced inflammatory cytokine TNF-α released from PBMCs, showing an anti-inflammation potential. Furthermore, ACW did not stimulate the rat basophilic leukemia cell (RBL-2H3) related allergy response on de-granulation. Our data presented ACW with a strong anti-oxidative ability in a superoxide anion radical scavenging assay. In mass spectrometry information, magnesium and zinc ions demonstrated bio-functional detections for anti-inflammation as well as other metal ions such as potassium and calcium were observed. ACW also had minor tyrosinase and melanin decreasing activities in human epidermal melanocytes (HEMn-MP) without apparent cytotoxicity. In addition, the cell proliferation assay illustrated anti-growth and anti-migration effects of ACW on human skin melanoma cells (A375.S2) indicating that it exerted the anti-cancer potential against skin cancer. The results obtained from biological assays showed that ACW possessed multiple bioactivities, including anti-microorganism, anti-inflammation, allergy-free, antioxidant, anti-melanin and anticancer properties. To our knowledge, this was the first report presenting these bioactivities on ACW.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.