Modifications on the Basic Skeletons of Vinblastine and Vincristine

Molecules

Péter Keglevich¹  László Hazai¹  György Kalaus¹ 

[1] Department of Organic Chemistry and Technology, University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Hungary

关键词: antitumor therapy;    vinblastine;    vincristine;    derivatives;   

DOI  :  10.3390/molecules17055893

来源: mdpi

【 摘 要 】

The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.