Design and Synthesis of Binding Growth Factors

International Journal of Molecular Sciences

Seiichi Tada¹  Takashi Kitajima¹ 

[1] Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;

关键词: growth factor;    immobilization;    protein engineering;    tissue engineering;    collagen;    peptide ligation;   

DOI  :  10.3390/ijms13056053

来源: mdpi

【 摘 要 】

Growth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements in their performance would be desirable for therapeutic applications. Conferring binding affinities would be one way to improve their applicability. Here we review techniques for conjugating growth factors to polypeptides with particular affinities. Conjugation has been designed at the level of gene fusion and of polypeptide ligation. We summarize and discuss the designs and applications of binding growth factors prepared by such conjugation approaches.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.