International Journal of Environmental Research and Public Health | |
Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents | |
Ian G. Cowell1  | |
关键词: topoisomerase II; TOP2; translocation; leukemia; AML; etoposide; mitoxantrone; epirubicin; transcription; carcinogen; | |
DOI : 10.3390/ijerph9062075 | |
来源: mdpi | |
【 摘 要 】
Type II DNA topoisomerases have the ability to generate a transient DNA double-strand break through which a second duplex can be passed; an activity essential for DNA decatenation and unknotting. Topoisomerase poisons stabilize the normally transient topoisomerase-induced DSBs and are potent and widely used anticancer drugs. However, their use is associated with therapy-related secondary leukemia, often bearing 11q23 translocations involving the
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190044231ZK.pdf | 426KB | download |