A Novel Preparation Method for 5-Aminosalicylic Acid Loaded Eudragit S100 Nanoparticles

International Journal of Molecular Sciences

Daode Hu²  Liang Liu²  Wenjuan Chen²  Sining Li¹ 

[1] College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; E-Mail:;Department of Clinical Pharmacology, Shanghai First People’s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200080, China; E-Mails:

关键词: supercritical antisolvent;    solution enhanced dispersion by supercritical fluids;    Eudragit S100;    5-ASA;    nanoparticles;    colon-specific;   

DOI  :  10.3390/ijms13056454

来源: mdpi

【 摘 要 】

In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. The effects of various process variables including pressure, temperature, 5-ASA concentration and solution flow rate on morphology, particle size, 5-ASA loading and entrapment efficiency of nanoparticles were investigated. Under the appropriate conditions, drug-loaded nanoparticles exhibited a spherical shape and small particle size with narrow particle size distribution. In addition, the nanoparticles prepared were characterized by X-ray diffraction, Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses. The results showed that 5-ASA was imbedded into EU S100 in an amorphous state after SEDS processing and the SEDS process did not induce degradation of 5-ASA.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.