Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain

Molecules

Jan Marek¹  Vladimir Buchta¹  Ondrej Soukup¹  Petr Stodulka¹  Jiri Cabal¹  Kallol K. Ghosh¹  Kamil Musilek¹ 

[1] ¹Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, 50001, Czech Republic

关键词: quinolinium salts;    synthesis;    HPLC;    surfactants;    detergents;    disinfectants;    in vitro antimicrobial activity;   

DOI  :  10.3390/molecules17066386

来源: mdpi

【 摘 要 】

Quaternary quinolinium salts differing in alkyl chain length are members of a widespread group of cationic surfactants. These compounds have numerous applications in various branches of industry and research. In this work, the preparation of quinoline-derived cationic surface active agents differing in the length of the side alkyl chains (from C₈ to C₂₀) is described. An HPLC method was successfully developed for distinction of all members of the series of prepared long-chain quinolinium derivatives. In conclusion, some possibilities of intended tests or usage have been summarized. In vitro testing using a microdilution broth method showed good activity of a substance with a C12 chain length against Gram-positive cocci and Candida species.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.