Biodegradation Study of Microcrystalline Chitosan and Microcrystalline Chitosan/β-TCP Complex Composites

International Journal of Molecular Sciences

Luciano Pighinelli¹  Magdalena Kucharska²  Maria Wísniewska-Wrona²  Bogdan Gruchaᐪ² 

[1] Institute of Biopolymers and Chemical Fibers—IBWCh, Sklodowskiej-Curie 19/27, Lodz, 90-570, Poland;

关键词: microcrystalline chitosan (MCCh);    calcium phosphate;    biodegradation;    hard tissue regeneration;   

DOI  :  10.3390/ijms13067617

来源: mdpi

【 摘 要 】

Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. This study compares the biodegradation process, bioactivity, structure, morphology, and mechanical properties of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex; the latter according to the new method of preparation. The complex showed a homogeneous network structure with regular pores, good bioactivity, even after 60 days of conducting the hydrolytic and enzymatic degradation process, showing a bacteriostatic and bactericidal activity. The complex indicates that it could be used successfully as a base for implants and scaffolds production in orthopedic surgery.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.