International Journal of Molecular Sciences | |
Effects of Methylmercury Contained in a Diet Mimicking the Wayana Amerindians Contamination through Fish Consumption: Mercury Accumulation, Metallothionein Induction, Gene Expression Variations, and Role of the Chemokine CCL2 | |
Jean-Paul Bourdineaud2  Muriel Laclau2  Régine Maury-Brachet2  Patrice Gonzalez2  Magalie Baudrimont2  Nathalie Mesmer-Dudons2  Masatake Fujimura1  Aline Marighetto4  David Godefroy3  William Rostène3  | |
[1] National Institute for Minamata Disease, Pathology Section, Department of Basic Medical Sciences, 4058-18 Hama, Minamata, Kumamoto 867-0008, Japan; E-Mail:;Bordeaux University-CNRS, UMR EPOC 5805, Arcachon Marine Station, Place du Docteur Peyneau, Arcachon, 33120, France; E-Mails:;Institut de la Vision, UMRS 968, INSERM-University Pierre et Marie Curie, 17 Rue Moreau, Paris, 75012, France; E-Mails:;Laboratoire de Neurosciences Cognitives, Bordeaux University-CNRS UMR 5106, Avenue des Facultés, Talence, 33405, France; E-Mail: | |
关键词: methylmercury; fish consumption; chemokine; mercury accumulation; metallothionein; demethylation; | |
DOI : 10.3390/ijms13067710 | |
来源: mdpi | |
【 摘 要 】
Methylmercury (MeHg) is a potent neurotoxin, and human beings are mainly exposed to this pollutant through fish consumption. We addressed the question of whether a diet mimicking the fish consumption of Wayanas Amerindians from French Guiana could result in observable adverse effects in mice. Wayanas adult men are subjected to a mean mercurial dose of 7 g Hg/week/kg of body weight. We decided to supplement a vegetarian-based mice diet with 0.1% of lyophilized
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
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