International Journal of Molecular Sciences | |
Role of Helicity on the Anticancer Mechanism of Action of Cationic-Helical Peptides | |
Yi-Bing Huang2  Li-Yan He2  Hong-Yu Jiang1  | |
[1]The First Hospital, Jilin University, Changchun 130021, China | |
[2]Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, China | |
[3] E-Mails: | |
关键词: anticancer peptides; helicity; hydrophobicity; mechanism of action; specificity; | |
DOI : 10.3390/ijms13066849 | |
来源: mdpi | |
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【 摘 要 】
In the present study, the 26-residue amphipathic α-helical peptide A12L/A20L (Ac-KWKSFLKTFKSLKKTVLHTLLKAISS-amide) with strong anticancer activity and specificity was used as the framework to study the effects of helicity of α-helical anticancer peptides on biological activities. Helicity was systematically modulated by introducing
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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