International Journal of Molecular Sciences | |
By-Passing Large Screening Experiments Using Sequencing as a Tool to Identify scFv Fragments Targeting Atherosclerotic Lesions in a Novel |
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Kamel Deramchia1  Marie-Josee Jacobin-Valat1  Jeanny Laroche-Traineau1  Stephane Bonetto1  Stephane Sanchez1  Pierre Dos Santos2  Philippe Massot1  Jean-Michel Franconi1  Pierre Martineau3  | |
[1] Magnetic Resonance Center of Biological Systems, UMR 5536, National Center for Scientific Research, Bordeaux Segalen University, 33076 Bordeaux Cedex, France; E-Mails:;Technology Platform for Biomedical Innovation, Bordeaux Segalen University, 33600 Bordeaux Cedex, France; E-Mail:;MCRI, Montpellier Cancer Research Institute, INSERM, U896, Montpellier1 University, CRLC Val d’Aurelle Paul Lamarque, Montpellier, F-34298, France; E-Mail: | |
关键词:
atherosclerosis;
human antibody;
single-chain variable fragment (scFv);
semi-synthetic phage display library;
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DOI : 10.3390/ijms13066902 | |
来源: mdpi | |
【 摘 要 】
Atherosclerosis is a chronic, progressive inflammatory disease that may develop into vulnerable lesions leading to thrombosis. To interrogate the molecular components involved in this process, single-chain variable fragments (scFvs) from a semi-synthetic human antibody library were selected on the lesions induced in a rabbit model of atherosclerosis after two rounds of
【 授权许可】
CC BY
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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