Two New Oxysporone Derivatives from the Fermentation Broth of the Endophytic Plant Fungus Pestalotiopsis karstenii Isolated from Stems of Camellia sasanqua

Molecules

Du Qiang Luo¹  Lei Zhang¹  Bao Zhong Shi¹ 

[1] ¹Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China ²College of Life Science, Hebei University, Baoding 071002, China

关键词: Pestalotiopsis karstenii;    secondary metabolites;    pestalrone A;    pestalrone B;   

DOI  :  10.3390/molecules17078554

来源: mdpi

【 摘 要 】

Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3,4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC₅₀ values of 12.6, 31.7 and 5.4 µg/mL, respectively.

【 授权许可】

CC BY   
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