A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives

Molecules

Augusto Rivera¹  Mauricio Maldonado¹ 

[1] Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Cra.30 No.45-03, Bogotá 111321, Colombia

关键词: benzimidazole-2-thione;    benzimidazole;    sulfur chemistry;    aminal cage;   

DOI  :  10.3390/molecules17078578

来源: mdpi

【 摘 要 】

A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, ¹H-, ¹³C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%–51.4% yield.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.