Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering

Polymers

Ahmed Alrifaiy¹  Olof A. Lindahl¹ 

[1] Department of Computer Science, Electrical and Space Engineering, Luleå University of Technology, SE-971 87 Luleå, Sweden;

关键词: microfluidics;    tissue engineering;    biomedical engineering;    polymers;    biocompatibility;    cell sorting;    cell analysis;    cell biology;   

DOI  :  10.3390/polym4031349

来源: mdpi

【 摘 要 】

This paper reviews microfluidic technologies with emphasis on applications in the fields of pharmacy, biology, and tissue engineering. Design and fabrication of microfluidic systems are discussed with respect to specific biological concerns, such as biocompatibility and cell viability. Recent applications and developments on genetic analysis, cell culture, cell manipulation, biosensors, pathogen detection systems, diagnostic devices, high-throughput screening and biomaterial synthesis for tissue engineering are presented. The pros and cons of materials like polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), polystyrene (PS), polycarbonate (PC), cyclic olefin copolymer (COC), glass, and silicon are discussed in terms of biocompatibility and fabrication aspects. Microfluidic devices are widely used in life sciences. Here, commercialization and research trends of microfluidics as new, easy to use, and cost-effective measurement tools at the cell/tissue level are critically reviewed.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.